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Category:MobilesActivation of c-Jun N-terminal kinase signaling pathway in the dentate gyrus of the hippocampus of postnatal cerebral ischemia/hypoxic rats.
We have investigated the involvement of the c-Jun N-terminal kinase (JNK) cascade signaling pathway in ischemia/hypoxic-induced apoptosis. To this end, we determined the expression of p21(Waf1/Cip1) and bax, two proteins known to be implicated in apoptotic cell death, in the different cell layers of the dentate gyrus of sham and ischemic/hypoxic rats. Cell death and the expression of p21(Waf1/Cip1) and bax were examined 3 days after the ischemic/hypoxic insult. Our results showed a preferential activation of JNK in the granule cells of the dentate gyrus of ischemia/hypoxic rats and an increase in p21(Waf1/Cip1) levels in the dentate gyrus, especially in the outer molecular layer of ischemic/hypoxic rats. This coincided with an increase in the number of apoptotic cells in the dentate gyrus. An increase in bax levels was also found in ischemic/hypoxic rats. We concluded that the JNK cascade activation plays a role in ischemia/hypoxic-induced apoptosis in the dentate gyrus of the hippocampus.var test = require(‘tape’);
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