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Renal ischemia-reperfusion causes cell damage (apoptosis) of the renal tubular epithelium. Ischemic preconditioning (IPC) protects against renal ischemia-reperfusion injury. However, whether it protects against L-arginine-induced acute renal failure, a novel animal model of ischemic-type AKI, is unclear. Rats were randomized into four groups: C, control; IP, IPC; LIARG and LARG, L-arginine (100 mg/kg) and L-arginine + IPC, respectively. After 24 h, rats underwent unilateral renal ischemia (infrarenal aorta) for 30 min. The rates of tissue apoptosis were evaluated by TUNEL and the expression of the bcl-2 and p53 genes was evaluated in the renal tubules. Compared with the C group, the percentage of TUNEL-positive cells was significantly increased in the IP and LIARG groups, but not in the LARG group. The bcl-2 gene was decreased in the IP and LIARG groups, and p53 in the IP group. IPC did not protect against the renal tubular apoptosis induced by L-arginine in the rat.Q:
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